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Spawns an aggressive attack fly that chases Isaac.

Spawns a Gaper that chases Isaac.

Spawns a spider that jumps at Isaac.

Spawns a maggot near Isaac.

Spawns a Charger that rushes in a straight line.

Spawns a Hopper that leaps toward Isaac.

Spawns a Pooter that flies and shoots tears.

Spawns a Horf that shoots projectiles.

Spawns a Clotty that shoots tears in four directions.

Spawns a Boom Fly that bounces and explodes on death.

Spawns a floating Maw that shoots at Isaac.

Spawns a Globin that regenerates when killed.

Spawns a Boil that shoots at Isaac.

Spawns a Spitty that spits a burst of tears.

Spawns an armored Knight (invulnerable from the front).

Spawns a Leech near Isaac.

Spawns a Vis that fires a Brimstone beam. Deadly.

Spawns a Sucker that homes in on Isaac.

Spawns a Bony skeleton that shoots bones.

Spawns a Gurgle that charges at Isaac.

Spawns a Round Worm that burrows and lunges.

Spawns a Keeper that shoots coins.

Spawns Monstro as a mini-boss near Isaac.

Spawns the Larry Jr. worm boss.

Spawns the Chub boss.

Spawns the Duke of Flies, who spawns a swarm of flies.

Spawns the Pin boss.

Spawns Gemini: the big body charging around with its baby in tow.

Spawns Steven, the black-and-white face of Gemini.

Spawns The Blighted Ovum, the bloody face of Gemini with its ghost baby.

Spawns The Hollow, the bony face of Larry Jr.

Spawns a Tuff Twin from the Mines: a Larry Jr. worm in rock armor, immune to anything but explosions until it breaks — and faster as it does.

Spawns The Shell, the other Mines twin: the same armored worm in its posthumous form.

Spawns C.H.A.D., the Chub variant that leaves blood trails.

Spawns The Carrion Queen, the Chub variant that fires tears in rings.

Spawns Scolex, the Pin variant that dives and comes back up firing.

Spawns The Frail, the skeletal Pin variant.

Spawns Wormwood, the Pin variant that lunges out of pits. It opens a few pits in the floor to surface from — without them it can only wander underground.

Spawns Delirium, the final boss of The Void: 10,000 HP, teleports around and morphs into bosses already seen in the run. Practically a run-ender.

Spawns a random enemy from the whole catalogue. Each one is a different surprise.

Spawns one of the mini-bosses at random (Monstro, Larry Jr., Chub, Duke of Flies, Gemini or Pin).

Spawns Gemini in one of its three faces at random: Gemini, Steven or The Blighted Ovum.

Spawns Chub in one of its three faces at random: Chub, C.H.A.D. or The Carrion Queen.

Spawns the Larry Jr. worm in one of its four faces at random: Larry Jr., The Hollow, Tuff Twin or The Shell.

Spawns Pin in one of its four faces at random: Pin, Scolex, The Frail or Wormwood.

Spawns a horde of mixed aggressive enemies around Isaac.

Kills every enemy in the current room.